Unified classification and risk-stratification in Acute Myeloid Leukemia
Dr. Elli Papaemmanuil et al. published the paper Unified classification and risk-stratification in Acute Myeloid Leukemia in Nature Communications. In it they use use comprehensive molecular profiling...
View ArticleSingle-cell genomic variation induced by mutational processes in cancer
Dr. Sohrab Shah et al. published the paper Single-cell genomic variation induced by mutational processes in cancer in Nature. How cell-to-cell copy number alterations that underpin genomic instability...
View ArticleOvarian cancer mutational processes drive site-specific immune evasion
Dr. Sohrab Shah et al. published the paper Ovarian cancer mutational processes drive site-specific immune evasion in Nature. High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic...
View ArticleGenetics and anatomy sculpt immune-cell partners of ovarian cancer
Genetics and anatomy sculpt immune-cell partners of ovarian cancer was recently published in Nature. The most common type of ovarian cancer, called high-grade serous ovarian cancer (HGSOC), is...
View ArticlePersonalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
Dr. Benjamin Greenbaum et al. published the paper Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients, yet...
View ArticleClonal evolution during metastatic spread in high-risk neuroblastoma
Dr. Elli Papaemmanuil et al. published the paper Clonal evolution during metastatic spread in high-risk neuroblastoma. Patients with high-risk neuroblastoma generally present with widely metastatic...
View ArticleIdentification of transcriptional programs using dense vector representations...
Dr. Nicholas Ceglia et al. published the paper Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector. A scalable framework for...
View ArticleInferring replication timing and proliferation dynamics from single-cell DNA...
Dr. Adam Weiner published the paper Inferring replication timing and proliferation dynamics from single-cell DNA sequencing data. The study explores how dysregulated DNA replication is a cause and a...
View ArticleAutomated real-world data integration improves cancer outcome prediction
The digitization of health records and growing availability of tumour DNA sequencing provide an opportunity to study the determinants of cancer outcomes with unprecedented richness. Patient data are...
View ArticleObesity-dependent selection of driver mutations in cancer
Obesity is a risk factor for cancer, but whether obesity is linked to specific genomic subtypes of cancer is unknown. We examined the relationship between obesity and tumor genotype in two...
View Article